What is metformin and how does it work?
Metformin has a long history dating back hundreds of years. Galega officinalis was a prominent medical herb in Europe for digestive health, urinary difficulties, and other diseases. Then, in 1918, a scientist discovered that guanidine, one of the components, might help lower blood sugar levels. Diabetes is treated with guanidine-containing medications such as metformin and phenformin. However, they went out of favour as a result of phenformin's severe side effects and the discovery of insulin.